KATAKATAKA AND NEEM LEAVES INTO PLANT BASE ANTIMYCOTIC CREAM

Abstract

This study aims to develop a plant-based antimycotic cream utilizing the antifungal properties of katakataka and neem leaf extracts. The research seeks to determine the feasibility of using these natural extracts in a topical formulation for treating fungal infections. Additionally, proper extraction methods are employed to obtain bioactive compounds, ensuring a concentrated extract rich in antifungal components. These extracts are then incorporated into a cream base to produce an effective plant-derived antimycotic product. The researchers recruited two groups of participants: five dermatologists and five chemical engineers. A structured questionnaire was administered to evaluate the acceptability of katakataka and neem leaf extracts as an antimycotic cream. The questionnaire covered aspects such as ingredients used, fragrance and odor, ease of application, expected relief duration, and overall presentation. The study assessed the acceptability of the plant-based antimycotic cream based on expert evaluations. Dermatologists provided an overall weighted mean of 3.29 with a variance of 0.028, while chemical engineers gave an overall weighted mean of 3.27 with a variance of 0.00325, both interpreted as highly acceptable. Statistical analysis yielded a t-computed value of 0.2530 and a t-critical value of 2.036 at a 0.05 significance level with 8 degrees of freedom. Since the t-critical value exceeded the t-computed value, the null hypothesis was accepted, confirming no significant difference between the assessments of the two groups. Based on the study results, respondents provided recommendations to further improve the antimycotic cream. Suggestions included enhancing the scent and effectiveness by incorporating additional natural ingredients, such as guava leaves, known for their medicinal properties. Other recommendations emphasized clear labeling of hazardous compounds, developing a step-by-step formulation guide, and designing visually appealing packaging to attract consumers.