KATAKATAKA (KALANCHOE PINNATA) AND NEEM LEAVES (AZADIRACHTA INDICA) INTO A PLANT BASED ANTI-MYCOTIC CREAM

Abstract

This study evaluated the antifungal properties of katakataka (Kalanchoe pinnata) and neem (Azadirachta indica) leaf extracts, emphasizing their potential as sustainable and safer alternatives to synthetic treatments. Their effectiveness supports the growing shift toward natural solutions in dermatological care. This study utilized an experimental research design and involved five dermatologists and five chemistry teachers as respondents. Data were gathered through a validated survey questionnaire. The formulation process included the collection, extraction, and combination of Katakataka (Kalanchoe pinnata) and Neem (Azadirachta indica) leaves with natural ingredients such as beeswax, olive oil, and glycerin. Data analysis was conducted using percentages, weighted mean, and t-test to determine variations in the respondents’ evaluations. The plant-based antifungal cream was evaluated by two respondent groups: dermatologists and chemistry teachers. Of the participants, 60% had clinical backgrounds, 20% were from laboratory-based disciplines, and the remaining 20% were involved in engineering and education. Regarding years of service, 50% had one to five years of experience, 30% had six to ten years, 10% had eleven to fifteen years, and 10% had less than a year.  The cream was assessed based on five criteria: ingredients and procedure, moisturizing properties, antifungal efficacy, skin suitability, and presentation. Dermatologists rated the cream highly across all categories, with scores ranging from 3.92 to 4.00, and an average rating of 3.71, indicating a high level of acceptability. Chemistry teachers gave slightly lower ratings, with scores ranging from 2.48 to 3.88 and an overall weighted mean of 2.96, still interpreted as acceptable. The combined overall mean from both groups was 3.34, suggesting the formulation is generally well-accepted. Although differences were observed between the two groups, particularly in skin suitability and antifungal efficacy—a t-test revealed no statistically significant difference (t = -2.08, p > 0.05), supporting the cream’s overall acceptability. The study assessed a plant-based anti-mycotic cream derived from neem and katakataka leaf extracts, which showed strong antifungal effectiveness. However, concerns such as imprecise ingredient measurements and a foamy texture were noted. Experts recommended improving the formulation process, using natural stabilizers, and conducting further tests to ensure skin safety and long-term efficacy. Enhancements in packaging were also suggested to improve product presentation and user experience.