Effect of Onion (Allium Cepa) Extracts to the Locomotor Activity of Young Male Albino Mice (Mus Musculus Domesticus)

Abstract

Due to the fast phase world, people are experiencing too much exhaustion and stress caused by school or work which can affect physical health. Thus, this study aimed to produce an alternative medicine for a muscle relaxant. Albino mice were utilized as the test subjects of the study; mice were given different amounts of onion extract. Oral gavage was used as the administration method. Data were obtained from the tests then compared to mice given with regular food and water and to those administered with commercial niacin dissolved in water as the controlled groups. Four types of tests were conducted specifically acute toxicity test, rotarod test, hole board test and inverted screen test. These tests determined the effect of onion extract and commercial niacin upon the locomotor activity and anxiousness of the albino mice. 1.6 mL was recorded to be the lethal dose of onion extract on albino mice. Mice group E, which consumed 1.2 mL of extract produced the lowest overall mean in accordance to the rotarod and inverted screen test while mice group A which was fed with regular food and water produced the highest overall mean on these tests. Hole board test showed that the locomotor activities of mice were reduced. There is an existing significant value gap between the overall means of mice groups in the rotarod test and locomotion. Based on the experiments conducted, the onion extract had a significant effect on the muscle relaxant activity of the mice regarding locomotion and rotarod test.