Binding Activity of Mucilage from Opuntia cochenilliferaon Hardness and Disintegration Time of Tablets

Abstract

INTRODUCTION

A pharmaceutical drug is outlined as a drug employed in health care. An example of this is a tablet. Excipients help streamline and facilitate the absorption of the drug. Using synthetic polymers can have negative effects on worker'shealth and tablet quality. This study aimed to determine the potential of using Opuntia cochenillifera mucilage in making a tablet binder to solve an increase in expenditure for producing synthetic polymers commonly used in tablet binding.

METHODS

After verifying the plant, the mucilage of Opuntia cochenillifera was extracted through the ethanolic method. Sixty grams of collected mucilage was freeze-dried which was turned into granules using the wet granulation method. The mucilage and granules were subjected to flowability tests, where tablets were subjected to disintegration time and hardness. Correlation Analysis was used to analyze the data.

RESULTS

The angle of repose of the mucilage and granules were 26.57 degrees and 11.31 degrees respectively. The bulk and tapped density volume for the mucilage and granules were 6.8 ml, 6.55 ml, and 8.4 ml and 8.1 ml. Percent Compressibility index and Hausner's ratio for mucilage and granules were 2.94%, 1.03% and 3.6%, 1.03%. There was a high linear positive relationship (0.8147) between the tablet hardness and the disintegration time of the placebo tablets -the higher the tablet hardness, the longer the disintegration time.

DISCUSSIONS

All of the results of flowability tests exhibited excellent flow character. The tablets produced had passed the disintegration time and hardness test. To sum up, mucilage from Dilang baka can be used as a tablet binder.