Chronotherapeutic Effects of Cyanocobalamin in Vitamin B12-Deficient Hamster (Cricetinae)
Keywords:
Chronotherapy, Biological Clock, Cyanocobalamin, OmeprazoleAbstract
INTRODUCTION
Biological clockshelp us maintain and control our physiological activities. These change on a daily, seasonal, yearly, or another regular cycle. A scientist cannot determine the right time to take medicines. Many medical experimentations and researches were applied, but there is no strong evidence and results to clarify this investigation. Finding the right time to take medicines in humans can help find the biological rhythm of the body, thereby increasing the survival rate of human beings.
METHODS
To conduct the study, five Hamsters (Cricetinae) with the same mass and age were gathered and were treated by Omeprazole to lower their Vitamin B12. Four of them compose the experimental group while the other one is the control. Using the process of Chronotherapy, hamsters from the experimental group were treated by Cyanocobalamin, a medicine that helps stabilize the Vitamin B12 level. Each of them was treated at different times and the data were collected through quantitative and qualitative analyses based on the changes in the appearance and mass of the hamsters.
RESULTS
After treating the experimental group with Omeprazole, the hamsters became anemic. This manifested in the thinning of hair and weight loss as a result of vitamin B12 deficiency. The control group, however, continued to be healthy. During the treatment of the experimental group, development rate among the hamsters differed. The medicine given to the hamster in the morning showed faster development than the rest of the hamsters in the experimental group. The group being treated during midnight showed very slow development.
DISCUSSIONS
A group of Vitamin B12-deficient hamsters was kept and treated on different time schedules. After comparing results, it was concluded that medications should be geared in sync with the biological rhythms of animals. inthe case of hamsters, the medication should be given early in the morning when the hamsters are resting.
