Antiseptic and Healing Properties of Kuribetbet (Tabernaemontana Pandacaqui Poir) Leaves' Extract versus Povidone-Iodine Solution

Abstract

Introduction

This study was conducted to determine the antiseptic effects and healing properties of Kuribetbet leaves' extract versus povidone-iodine solution about: (a) degree of redness, (b) size of wound inflammation, (c) quality of wound discharge, (d) contraction of wound, and (d) duration of wound healing; likewise, the effects of Kuribetbet leaves' extract versus povidone-iodine solution was determined on the hemoglobin counts and weight of the rabbits.

Methods

The Completely Randomized Design (CRD) with three replicates was used with three rabbits assigned in each replicate. The treatments were:

Treatment 1 –Kuribetbet Leaves Extract

Treatment 2 –Betadine Solution (10%)

Treatment 3 –Natural Healing (Control)

Nine Mongolian breed rabbits were used in the study. Weights of the experimental rabbits before and after the experiment were significantly different; hence, the data were analyzed using the Analysis of Covariance (ANACOVA) Hemoglobin content ranged from 11.43 to 14.67 g/L.

Results

Based on the duration of the wound healing of rabbits, the wounds, treated with Kuribetbet leaves extract was 4 days; the Betadine solution was 6 days, and Natural Healing was 7 days. Kuribetbet leaves extract is a potential alternative source of antiseptic for wounds as practiced by the rural folks in Pangasinan and La Union.

Discussions

Degree of redness in rabbits' wound sites developed in all the wounds from day 1 to day 3. Rabbit wounds treated with the Kuribetbet leaves extract had a scale value of (pink) on day 3; Betadine treatment zero scale value (pink) on day 5; and those on Natural Healing scale value of zero (pink) on day 6. Kuribetbet leaves' extract reduced the rabbit's wounds' degree of redness in 3 days which was much faster than the Betadine Solution of 5 days. Size of wound inflammation on the incised rabbit wounds developed on day 1 and was noticeable up today 4. Wound inflammation on rabbits treated with Kuribetbet leaves extract subsided on day 6, and rabbits wound on Natural Healing subsided on day 6. Kuribetbet leaves extract reduced the rabbit wound inflammation or swelling faster of 4 days than the Betadine solution of 6 days. The effect of the Kuribetbet leaves extract on the incised wound rabbits in terms of wound discharged was comparable with that of the Betadine solution where both treatments prevented the formation of liquid in the inflamed or swollen area on the rabbit wounds.