Anti-ulcerogenic Properties of Tit Berry (Allophylus cobbe) Leaves, Roots, and Bark Extracts in Mature Female Mice (Mus musculus)

Abstract

INTRODUCTION

A study by Prasad, Shyma, and Raghavendra (2013) discovered that a certain tribe inIndia was using leaf extracts of Tit berry (Allophylus cobbe) to cure ulcer. However, there are no scientific studies yet proving the anti-ulcerogenic properties of the said plant. Thus, in this paper, the anti-ulcerogenic properties of Tit berry extractsagainst gastric ulcer were investigated. Specifically, this study was conducted to determine the anti-ulcerogenic effects of the different parts of Tit Berry in terms of the pH level, ulcer index, and curative percentage.

METHODS

This experimental research was conducted at the R&V Veterinary Clinic. Twelve mice were fasted one day before the experimentation and then given NSAID to induce ulceration. Then the treatments were given to the mice four hours after the ulcer induction: T0 -Omeprazole, the controlled treatment; T1 -Leaves extract; T2 -Roots extract; and T3 -Bark extracts. Afterward, the mice were euthanized and were dissected after eight hours. The pH level, ulcer index, and curative percentage of the mice were then observed and recorded.

RESULTS

The gathered data from the experiment were interpreted using the adopted scoring system from Choudhary, Bodakhe, and Gupta (2013), Qadir (2019), and MedLine Plus (2018) to assess the pH level, ulcer index, and curative percentage of the mice. The results showed that the T3¬ yielded the best ulcer index with a weighted mean score of 1.00 and the best curative percentage with a mean score of 2.00. Moreover, T1 produced the best pH level with a weighted mean score of 1.67. The 5-point Likert scale showed that the treatment with the lowest weighted means had the most effective anti-ulcerogenic properties. Because of this, T1 is considered the most effective treatment since it yielded the lowest mean score. These results proved that the Tit berry plant extracts possess anti-ulcerogenic properties, which includes the pH level, ulcer index, and curative percentage.

DISCUSSIONS

Therefore, even though T3 had the best ulcer index and curative percentage, its pH level is the least of all treatments making it the second most effective treatment. To conclude, results showed that T1 of the Tit berry yielded the most effective anti-ulcerogenic properties since it produced the best mean score, which means that it consistently achieved the expected results.